Pure mucinous carcinoma (MC) (with >90% mucinous component) is typically a slow-growing tumor with a better prognosis, lower rate of axillary nodal involvement, and better disease-free survival than invasive breast carcinoma, no special type. Pure MC is subdivided based on tumor cellularity, either hypocellular (type A) or hypercellular (type B). Invasive lobular carcinoma is the most common special breast carcinoma subtype, with unique morphological (discohesive cells, single-cell files, targetoid pattern) and immunohistochemical (loss of E-cadherin and β-catenin staining) features. Moreover, ILC displays a poor response to neoadjuvant therapy, a different metastatic pattern compared to invasive breast carcinoma of no special type All selected cases were diagnosed as invasive breast carcinomas, of no special type (NST), G2 grade of differentiation. The most frequently encountered subtype at both sites was luminal B. We determined that tumor profile evaluated by surrogate markers is not stable during the metastatic process. Pada umumnya, kanker payudara terbagi dalam 2 tipe kanker berdasarkan pemeriksaan mikroskopis, yaitu kanker payudara invasive ductal carcinoma dan invasive lobular carcinoma. Namun, kasus kanker invasive ductal carcinoma lebih banyak ditemukan. Dan penanganan kedua tipe kanker ini secara umum tidak berbeda. Grade 3 menunjukkan differentiated Breast carcinoma Invasive breast cancers are still organised into chap-ters by their morphological subtypes, which remain clinically relevant. However, as the majority of cases are of no special type (NST), additional prognostic and predictive factors that aid significantly in treat-ment and outcome stratification are also focused on . This suggests the existence of changes in the mammary gland in patients of group IIb similar to those present in patients with invasive carcinoma of no special type. Higher indices of polyclonal activators influence on the production of IL-1β, as well as the ratio of IL1β/IL1Ra were observed in the patients of group IIa compared to the In this study, we analyzed a comprehensive large retrospective breast cancer cohort with a special focus on histological subtype (other than ductal non-special type or lobular carcinoma) and correlated pure or mixed histological forms with pathological tumor stage and overall disease-free survival. Materials and methods Invasive ductal carcinoma of no special type - medullary pattern With the 5th Edition of the WHO Classification, medullary carcinoma ceased to be considered a distinct subtype of breast cancer Squamous carcinoma or squamous cell carcinoma. Squamous carcinoma or squamous cell carcinoma is a type of non-small cell lung cancer (NSCLC) where the cells look like the flat cells (called squamous cells) that line the airways. It is a common type of lung cancer in the United States. Breast tumors with neuroendocrine (NE) differentiation comprise an uncommon and heterogeneous group of tumors, including invasive breast cancer of no special type (IBC-NST) with NE features, neuroendocrine tumors (NETs), and neuroendocrine carcinoma (NEC). The most recent World Health Organization (WHO) classification in 2019 defined neuroendocrine neoplasms (NENs) of the breast (Br-NENs) as

invasive carcinoma of no special type